The School offers a wide variety of musical opportunities, including a chapel choir, Schola Cantorum, chamber choir, junior choir, symphony orchestra, chamber orchestra, brass ensemble, two jazz orchestras, a string orchestra, a contemporary music group, three wind bands, CCF Marching Band, percussion ensemble, Roc Soc, chamber music, pipe band, steel pans and many other ensemble groups.

The Choir's regular Sunday services encompass the broad range of the cathedral music repertory, and the various choirs have performed at St. Paul's Cathedral, Westminster Abbey, St George's Chapel, Windsor, Lincoln Cathedral, Southwell Minster, York Minster, St Martin-in-the-Fields and Merton College, Oxford.

Recent Symphony Orchestra repertoire has included Brahms Requiem, Vaughan-Williams Sinfonia Antartica. Concerti with student soloists are a regular feature of the academic year. There is a flourishing chamber music programme including senior and junior string quartets, wind ensembles and piano trios. As part of the regular sequence of Chapel services, there is an annual orchestral eucharist; recently Schubert Mass in G and Haydn Missa Sancti Nicolai have been performed.

Musicians gain further experience playing at Cadet Force ceremonies and in stage musicals in conjunction with the Stahl Theatre. A weekly Lunchtime Concert Series provides opportunities for solo and ensemble performance for all age groups, and are popular with members of the town community.

The School annually hosts a programme of performances by renowned ensembles, which has included London Brass, English String Orchestra, Orchestra of the Swan, Aurora Orchestra, Endellion String Quartet, Coull 4tet, Skampa Quartet and The Songmen. Additionally, School musicians are privileged to attend masterclasses with leading artists who also lead public performances at School.

A number of pupils have been selected for the National Youth Orchestra, the National Children's Wind Orchestra and the National Children's Orchestra. Many pupils at Oundle achieve diplomas before leaving and go on to music conservatoires or to instrumental or choral scholarships at university.